Journal article
Broad-Spectrum Solvent-free Layered Black Phosphorus as a Rapid Action Antimicrobial
ZL Shaw, S Kuriakose, S Cheeseman, ELH Mayes, A Murali, ZY Oo, T Ahmed, N Tran, K Boyce, J Chapman, CF McConville, RJ Crawford, PD Taylor, AJ Christofferson, VK Truong, MJS Spencer, A Elbourne, S Walia
ACS Applied Materials and Interfaces | AMER CHEMICAL SOC | Published : 2021
Abstract
Antimicrobial resistance has rendered many conventional therapeutic measures, such as antibiotics, ineffective. This makes the treatment of infections from pathogenic micro-organisms a major growing health, social, and economic challenge. Recently, nanomaterials, including two-dimensional (2D) materials, have attracted scientific interest as potential antimicrobial agents. Many of these studies, however, rely on the input of activation energy and lack real-world utility. In this work, we present the broad-spectrum antimicrobial activity of few-layered black phosphorus (BP) at nanogram concentrations. This property arises from the unique ability of layered BP to produce reactive oxygen specie..
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Awarded by Jack Brockhoff Foundation
Funding Acknowledgements
This work was performed in part at the Micro Nano Research Facility at RMIT University in the Victorian Node of the Australian National Fabrication Facility (ANFF). Facilities and technical support from the RMIT Microscopy and Microanalysis Facility, a node of Microscopy Australia, are acknowledged. The scholarship support from the Australian Postgraduate Award (APA)/Research Training Program (RTP) scheme of the Australian government is acknowledged (S.K.). We acknowledge equipment funding from the Australian Research Council through LE150100001. The computational work was undertaken with the assistance of supercomputing resources provided by the Australian Government through NCI, Pawsey, and MASSIVE under the National Computational Merit Allocation Scheme (project y41 and project kl59). The authors would like to acknowledge the kind support on fungal strains from Dr. Sarah Kidd from SA Pathology Laboratory. A.E. acknowledges the support from the Jack Brockhoff Foundation (JBF grant number 4655-2019).